&lt;h2&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;Overview&lt;/strong&gt;&lt;/span&gt;&lt;/h2&gt;
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&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Programmed Death-Ligand 1 (PD-L1) (SP263) semi-quantitative immunohistochemistry (IHC) is a manual laboratory technique used to evaluate the expression levels of PD-L1 protein in tissue samples. PD-L1 is a checkpoint protein found on tumor cells and immune cells within the tumor microenvironment. Its interaction with PD-1 receptors on T cells can suppress the immune response and allow cancer cells to evade detection and destruction by the immune system.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;In clinical practice, PD-L1 testing with the SP263 antibody is crucial for predicting the response of certain types of cancer to treatment with immune checkpoint inhibitors (ICIs). These inhibitors block the PD-1/PD-L1 pathway, thereby enhancing the ability of the immune system to recognize and attack cancer cells.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;The semi-quantitative nature of this IHC method involves scoring the extent and intensity of PD-L1 staining in tumor cells and immune cells. The results are reported as a percentage of positively stained cells or as a combined positive score (CPS).&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;This manual technique requires skilled laboratory personnel to perform tissue staining, followed by visual examination under a microscope and interpretation by pathologists or oncologists. It helps clinicians make informed decisions about treatment options, particularly with ICIs, by predicting response rates and guiding personalized therapy plans.&lt;/span&gt;&lt;/p&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Overall, PD-L1 (SP263) semi-quantitative immunohistochemistry plays a critical role in oncology by providing valuable information about the immune status of tumors and aiding in the selection of appropriate immunotherapy strategies for cancer patients based on PD-L1 expression levels in tumor tissue.&lt;/span&gt;&lt;/p&gt;
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&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;WHAT IS IT USED FOR?&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
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&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Detection of tumors expressing programmed cell death 1-ligand 1 (SP263 clone).&lt;/span&gt;&lt;/p&gt;
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&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;METHOD NAME&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Immunohistochemistry (IHC)&lt;/span&gt;&lt;/p&gt;
&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;&lt;br /&gt;AVAILABILITY&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
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&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;REPORTING NAME&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;PD-L1 (SP263) SemiQuant IHC, Manual&lt;/span&gt;&lt;/p&gt;
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&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;ALIASES&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;ul&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;PDL1&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;SP263&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;GPPDL1SP263&lt;/span&gt;&lt;/li&gt;
&lt;li&gt;&lt;span style=&quot;color: #808080;&quot;&gt;ISPDL1SP263IHC&lt;/span&gt;&lt;/li&gt;
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&lt;h3 id=&quot;SpecimenType-title&quot;&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;SPECIMEN TYPE&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;Special&lt;/span&gt;&lt;/p&gt;
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&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;SHIPPING INSTRUCTIONS&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p&gt;&lt;span style=&quot;color: #808080;&quot;&gt;TBC&lt;/span&gt;&lt;/p&gt;
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&lt;h3&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;SPECIMEN REQUIRED&lt;br /&gt;&lt;/strong&gt;&lt;/span&gt;&lt;/h3&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;Specimen Type:&lt;/strong&gt;&lt;/span&gt;&amp;nbsp;Tissue&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;&lt;strong&gt;Supplies:&lt;/strong&gt;&amp;nbsp;&lt;/span&gt;Pathology Packaging Kit (T554)&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;strong&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;Collection Instructions:&lt;/span&gt;&amp;nbsp;&lt;/strong&gt;Formalin-fixed, paraffin-embedded tissue block; or 3 unstained glass, &quot;positively charged&quot; slides with 4-microns formalin-fixed, paraffin-embedded tissue&lt;/span&gt;&lt;/p&gt;
&lt;p style=&quot;font-weight: 400;&quot;&gt;&lt;span style=&quot;color: #808080;&quot;&gt;&lt;strong&gt;&lt;span style=&quot;color: #33cccc;&quot;&gt;Additional Information:&lt;/span&gt;&amp;nbsp;&lt;/strong&gt;One slide will be stained with hematoxylin and eosin and returned.&lt;/span&gt;&lt;/p&gt;

Programmed Death-Ligand 1 (PD-L1) (SP263), Semi-Quantitative Immunohistochemistry, Manual